Search results for "Hepatic cell-targeted carriers"

showing 3 items of 3 documents

NOVEL COMPOSED GALACTOSYLATED NANODEVICES CONTAINING A RIBAVIRIN PRODRUG AS HEPATIC CELL-TARGETED CARRIERS FOR HCV TREATMENT

2013

In this paper, we describe the preparation of liver-targeted nanoparticles potentially able to carry to hepatocytes a ribavirin (RBV) prodrug, exploiting the presence of carbohydrate receptors in the liver (i.e., ASGPR in hepatocytes). These particles were obtained starting from a galactosylated phospholipid-polyaminoacid conjugate. This latter was obtained by chemical reaction of ALPHA, BETA -poly(N-2-hydroxyethyl) (2-aminoethylcarbamate)-DL-aspartamide (PHEA-EDA) with 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) sodium salt (DPPE), and subsequent reaction with lactose, obtaining PHEA-EDA-DPPE-GAL copolymer. To enhance the entrapment into obtained nanostructures, a hydroph…

Biomedical EngineeringPharmaceutical ScienceMedicine (miscellaneous)NanoparticleBioengineeringAntiviral AgentsDiffusionNon-competitive inhibitionNanocapsulesMaterials TestingRibavirinHumansGeneral Materials ScienceProdrugschemistry.chemical_classificationGalactoseHep G2 CellsProdrugCarbohydrateVirologyCombinatorial chemistryHepatitis CIn vitroGalactosylated Nanoparticles Hepatic Cell-Targeted Carriers Active Targeting Ribavirin Tripalmitate Hepatitis C.EnzymechemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoDrug deliveryConjugate
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Galactosylated micelles for a ribavirin prodrug targeting to hepatocytes.

2013

Polymeric micelles potentially able to carry to hepatocytes a ribavirin (RBV) prodrug, exploiting the presence of carbohydrate receptors, that is, ASGPR, were prepared starting from a galactosylated polylactide-polyaminoacid conjugate. This latter was obtained by chemical reaction of α,β-poly(N-2-hydroxyethyl) (2-aminoethylcarbamate)-dl-aspartamide (PHEA-EDA) with polylactic acid (PLA), and subsequent reaction with lactose, obtaining PHEA-EDA-PLA-GAL copolymer. To enhance the entrapment into obtained nanostructures, a hydrophobic RBV prodrug, that is, RBV tripalmitate, was synthesized and its capability to release RBV in the presence of an adequate enzymatic activity was demonstrated. Liver…

Magnetic Resonance SpectroscopyPolymers and PlasticsBioengineeringMicelleAntiviral AgentsBiomaterialschemistry.chemical_compoundNon-competitive inhibitionPolylactic acidRibavirinSpectroscopy Fourier Transform InfraredMaterials ChemistryCopolymerOrganic chemistryHumansProdrugsMicellesChemistrytechnology industry and agricultureGalactoseHep G2 CellsProdrugCarbohydrateCombinatorial chemistryIn vitroLiverSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoGalactosylated polymeric micelles hepatic cell-targeted carriers active targeting ribavirin tripalmitate hepatitis C.ConjugateBiomacromolecules
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Galactosylated polymeric carriers for liver targeting of sorafenib

2014

In this paper, we describe the preparation of liver-targeted polymeric micelles potentially able to carry sorafenib to hepatocytes for treatment of hepatocarcinoma (HCC), exploiting the presence of carbohydrate receptors, ASGPR. These micelles were prepared starting from a galactosylated polylactide-polyaminoacid conjugate. This latter was obtained by chemical reaction of α,β-poly(N-2-hydroxyethyl) (2-aminoethylcarbamate)-d,l-aspartamide (PHEA-EDA) with polylactic acid (PLA), and subsequent reaction with lactose, leading to PHEA-EDA-PLA-GAL copolymer. Liver-targeted sorafenib-loaded micelles were obtained in aqueous media at low PHEA-EDA-PLA-GAL copolymer concentration value with nanometer …

NiacinamideSorafenibBiodistributionPolyestersBiological AvailabilityPharmaceutical ScienceAntineoplastic AgentsPharmacologyKidneyMicellechemistry.chemical_compoundPolylactic acidHepatic cell-targeted carriersmedicineZeta potentialAnimalsLungneoplasmsMicellesDrug CarriersActive targetingPhenylurea CompoundsHepatic cell-targeted carrierGalactoseActive targeting; Galactosylation; Hepatic cell-targeted carriers; Polymeric micellesSorafenibEthylenediaminesdigestive system diseasesMice Inbred C57BLLiverBiochemistrychemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoGalactosylationDrug deliveryPolymeric micellesFemalePeptidesDrug carrierSpleenmedicine.drugConjugateInternational Journal of Pharmaceutics
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